Well, my first introduction to not being sufficiently acclimatised for altitude was in Chamonix. After a trip to Scotland, there I was trekking all day up the Mer de Glace in Chamonix, feeling atomic-powered and all, and even started running up the scree to the alpine hut at 10,000ft. Our route further was blocked so we descend to Chamonix at 3,000ft then cable car to around 13,000ft. I wobbled at bit, then felt fine. But then during the night, altitude sickness hit me like a sledge hammer, shivering and the rest of it. The extra 3,000ft in numbers, seemingly not a great rise. But I took four days to recover.
Anyway, I saw an excellent documentary about it. In fact ones susceptibility seems preset in each individual, and I was quite miffed to learn that even someone from a sedentary lifestyle could zip up to moderate altitude and might have no onset of altitude sickness in comparison to someone who is well trained. Though it is not generally the case. It also works the other way, as no amount of training can enable some people to acclimatise above a certain level. And that may be even a modest altitude.
Though the key to success is progression, especially over a number of years, where the body gains the ability to learn how to adapt quickly and retains a higher base level without ill effect. For big peaks, people ascend and then descend for a day or so, then keep doing this in stages of altitude until the last push or so. Beyond 25,000ft begins the death zone, where the body simply cannot maintain itself. There have been only a few ascents of Everest without additional oxygen.
So I guess biking above that is out. Well ascending, at least!
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